相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Design, Synthesis, and Structure-Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M3 Muscarinic Acetylcholine Receptor
Hiroaki Tanaka et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2021)
Current Advances in Allosteric Modulation of Muscarinic Receptors
Jan Jakubik et al.
BIOMOLECULES (2020)
Discovery and structure -activity relationships study of positive allosteric modulators of the M 3 muscarinic acetylcholine receptor
Hiroaki Tanaka et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice
Lu Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation
Aaron M. Bender et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Allosteric modulators targeting CNS muscarinic receptors
Andreas Bock et al.
NEUROPHARMACOLOGY (2018)
Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors
Wessel A. C. Burger et al.
JOURNAL OF GENERAL PHYSIOLOGY (2018)
Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
Jan Jakubik et al.
SCIENTIFIC REPORTS (2017)
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
Ron O. Dror et al.
NATURE (2013)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Kazuko Haga et al.
NATURE (2012)
Structure and dynamics of the M3 muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2012)
Allosteric Modulation of the M3 Muscarinic Receptor by Amiodarone and N-Ethylamiodarone: Application of the Four-Ligand Allosteric Two-State Model
Edward Stahl et al.
MOLECULAR PHARMACOLOGY (2011)
Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives
Stephan Urwyler
PHARMACOLOGICAL REVIEWS (2011)
Novel Allosteric Effects of Amiodarone at the Muscarinic M5 Receptor
Edward Stahl et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Allosteric Modulation of Muscarinic Acetylcholine Receptors
Jan Jakubik et al.
PHARMACEUTICALS (2010)
Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isatins
Thomas M. Bridges et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
P. Jeffrey Conn et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Muscarinic Receptor Subtypes in the Lower Urinary Tract
Daniel Giglio et al.
PHARMACOLOGY (2009)
Allosteric modulation of muscarinic acetylcholine receptors
Karen J. Gregory et al.
CURRENT NEUROPHARMACOLOGY (2007)
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Juergen Wess et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Allosteric interactions with muscarinic acetylcholine receptors:: Complex role of the conserved tryptophan M2 422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity
Stefanie Prilla et al.
MOLECULAR PHARMACOLOGY (2006)
Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor:: More similarities than differences between the structurally divergent agents gallamine and bis(ammonio) alkane-type hexamethylene-bis[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
XP Huang et al.
MOLECULAR PHARMACOLOGY (2005)
Reactivity of urinary bladder smooth muscle in guinea pigs to acetylcholine and carbachol: Participation of acetylcholinesterase
J Mokry et al.
PHYSIOLOGICAL RESEARCH (2005)
Cystometric findings in mice lacking muscarinic M2 or M3 receptors
Y Igawa et al.
JOURNAL OF UROLOGY (2004)
Signal transduction underlying carbachol-induced contraction of human urinary bladder
T Schneider et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast -: Identification of point mutations that silence a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling
C Schmidt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Allosteric site on muscarinic acetylcholine receptors:: Identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors
U Voigtländer et al.
MOLECULAR PHARMACOLOGY (2003)
Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors
S Lazareno et al.
MOLECULAR PHARMACOLOGY (2002)
M3 muscarinic receptors mediate contraction of human urinary bladder
C Fetscher et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Allosteric site on muscarinic acetylcholine receptors: A single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands
S Buller et al.
MOLECULAR PHARMACOLOGY (2002)
The minor population of M3-receptors mediate contraction of human detrusor muscle in vitro
R Chess-Williams et al.
JOURNAL OF AUTONOMIC PHARMACOLOGY (2001)
Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype
M Matsui et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
分享论文
