4.5 Article

Preemptive effects of ibuprofen and nimesulide on postoperative pain control after open flap periodontal surgeries: A randomized placebo-controlled split-mouth clinical trial

期刊

JOURNAL OF PERIODONTOLOGY
卷 93, 期 2, 页码 298-307

出版社

WILEY
DOI: 10.1002/JPER.20-0887

关键词

analgesia; ibuprofen; nimesulide; pain; pain management; postoperative; preanesthetic medication

资金

  1. National Council for Scientific and Technological Development (CNPq-Brasilia, Brazil)
  2. Coordination for the Improvement of Higher Education Personnel (CAPES-Brasilia, Brazil)
  3. Research Support Foundation of the State of Minas Gerais (FAPEMIG-Belo Horizonte, Brazil)

向作者/读者索取更多资源

This study evaluated and compared the analgesic effects of preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries. The results showed that nimesulide had better pain control effects at 24, 48, and 72 postoperative hours, indicating a higher overall preemptive effect.
Background Data on preemptive analgesia in periodontal surgeries are scarce and still diverse. The aim of this study was to evaluate and compare the analgesic effects of the preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries. Methods The present randomized controlled clinical trial comprised 40 individuals, divided into two groups (n = 20), according to the test drug (ibuprofen and nimesulide) to be administered 1 hour preoperatively. Participants underwent bilateral periodontal surgeries at two different times, and were randomly given the test drug or placebo in a split-mouth design. Postoperative pain and rescue medication were evaluated at different times. Comparisons between ibuprofen and nimesulide were performed through a Generalized Estimation Equation model, using test drug and evaluation times, along with an interaction between these two variables as predictors. Results In intergroup comparisons regarding pain control, ibuprofen showed better effects than placebo only at the first postoperative hour, whereas nimesulide showed better effects than placebo at 1, 6, 24, and 48 postoperative hours. In intergroup comparisons, nimesulide showed better effects than ibuprofen at 24, 48, and 72 postoperative hours, demonstrating a higher overall preemptive effect. No differences were observed in relation to the number of rescue medication. Conclusion Preemptive administration of nimesulide showed better overall preemptive effects on postoperative pain control when compared with ibuprofen.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据