期刊
JOURNAL OF PERIODONTOLOGY
卷 93, 期 6, 页码 877-887出版社
WILEY
DOI: 10.1002/JPER.21-0256
关键词
chronic pain; fatigue; infections; inflammation; musculoskeletal diseases; rheumatic diseases
资金
- Ministry of Science and Technology of the Republic of China (MOST), Taipei, Taiwan [MOST 108-2813-C-040-040-B]
- Ministry of Science and Technology of the Republic of China Clinical Trial Consortium for Stroke, Taipei, Taiwan [MOST 109-2321-B-039-002]
- Ministry of Health and Welfare Clinical Trial Center, Taipei, Taiwan [MOHW109TDU-B-212-114004]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- International Team for Implantology (ITI), Basel, Switzerland [1577_2021]
Periodontitis patients have a higher risk of developing fibromyalgia, especially males and younger patients. Additionally, fibromyalgia patients who never had periodontitis are at a greater risk of developing it over time.
Background To determine the bidirectional link between periodontitis and fibromyalgia. Methods In this cohort study, 196,428 periodontitis patients and 196,428 propensity score-matched non-periodontitis controls were enrolled. A Cox proportional hazard model was utilized to estimate the risk of fibromyalgia and survival analysis was adopted to assess the time-dependent effect of periodontitis on fibromyalgia. Subgroup analyses stratified by age, sex, and tracking period were conducted to identify susceptible populations. A parallel and symmetrical cohort that recruited 141,439 fibromyalgia patients and 141,439 propensity score-matched non-fibromyalgia controls ascertained the inverse effect of fibromyalgia on incident periodontitis. Results Patients with periodontitis were more likely to develop fibromyalgia than non-periodontitis controls (HR = 1.42, 95% CI = 1.39-1.44, P < 0.001), which persisted in the survival analysis (log-rank test P < 0.0001). This effect was significant in both sexes and all age subgroups, and was particularly evident in males (HR = 1.52, 95% CI = 1.48-1.56, P < 0.001) and younger periodontitis patients (HR = 1.55, 95% CI = 1.50-1.60, P < 0.001). Fibromyalgia patients who never had periodontitis presented with greater risk for periodontitis over time (HR = 1.43, 95% CI = 1.40 - 1.45, P P < 0.0001). Conclusions Patients of both sexes and all age subgroups with periodontitis presented with a greater risk of fibromyalgia. Subgroups that were the most susceptible to periodontitis-associated fibromyalgia were periodontitis patients that were males and below 30 years old. Risks of periodontitis were also greater in fibromyalgia patients who never had periodontitis.
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