期刊
JOURNAL OF PAIN
卷 22, 期 12, 页码 1722-1732出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jpain.2021.06.004
关键词
Prolonged hyperalgesia; nerve-growth factor; oscillations; electroencephalography; muscle soreness
资金
- Danish National Research Foundation [DNRF121]
The peak alpha frequency (PAF) decreases during cutaneous pain, but there is limited research on PAF during movement-related muscle pain. Individuals with high pain sensitivity (HPS) exhibit a faster PAF response to muscle pain, while long-lasting movement-related pain can lead to a decrease in PAF, indicating a widespread change in cortical excitability independent of pain sensitivity.
Peak alpha frequency (PAF) reduces during cutaneous pain, but no studies have investigated PAF during movement-related muscle pain. Whether high-pain sensitive (HPS) individuals exhibit a more pronounced PAF response to pain than low-pain sensitive (LPS) individuals is unclear. As a pain model, twenty-four participants received nerve growth factor injections into a wrist extensor muscle at Day 0, Day 2, and Day 4. At Day 4, a subgroup of twelve participants also undertook eccentric wrist exercise to induce additional pain. Pain numerical rating scale (NRS) scores and electroencephalography were recorded at Day 0 (before injection), Day 4, and Day 6 for 3 minutes (eyes closed) with wrist at rest (Resting-state) and extension (Contraction-state). The average pain NRS scores in contraction-state across Days were used to divide participants into HPS (NRS-scores >= 2) and LPS groups. PAF was calculated by frequency decomposition of electroencephalographic recordings. Compared with Day 0, contraction NRS-scores only increased in HPS-group at Day 4 and Day 6 (P < .001). PAF in Contraction-state decreased in both groups at Day 6 compared with Day 0 (P = .011). Across days, HPS-group showed faster PAF than LPS-group during Resting-state and Contraction state (P < .04). Average pain NRS-scores across days during Contraction-states correlated with PAF at Day 0 (P = .012). Pain NRS-scores were associated with PAF during Contraction-state at Day 4 and Day 6 (P < .05). Perspective: PAF was slowed during long-lasting movement-related pain in both groups, suggesting a widespread change in cortical excitability independent of the pain sensitivity. Moreover, HPS individuals showed faster PAF than LPS individuals during muscle pain, which may reflect a different cognitive, emotional, or attentional response to muscle pain among individuals. (C) 2021 by United States Association for the Study of Pain, Inc.
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