4.5 Article

Location of brachial plexus birth injury affects functional outcomes in a rat model

期刊

JOURNAL OF ORTHOPAEDIC RESEARCH
卷 40, 期 6, 页码 1281-1292

出版社

WILEY
DOI: 10.1002/jor.25173

关键词

brachial plexus; forelimb; gait; musculoskeletal model; rat model

资金

  1. National Institutes of Health [R21 HD088893]

向作者/读者索取更多资源

The study compared functional movement outcomes in rats with brachial plexus birth injury (BPBI) after preganglionic and postganglionic neurectomy, finding that the preganglionic neurectomy group spent less time in stance and exhibited less elbow flexion and shoulder protraction in the affected limb. Results indicate the presence of compensatory motor control strategies during locomotion following BPBI.
Brachial plexus birth injury (BPBI) results in shoulder and elbow paralysis with shoulder internal rotation and elbow flexion contracture as frequent sequelae. The purpose of this study was to develop a technique for measuring functional movement and examine the effect of brachial plexus injury location (preganglionic and postganglionic) on functional movement outcomes in a rat model of BPBI, which we achieved through integration of gait analysis with musculoskeletal modeling and simulation. Eight weeks following unilateral brachial plexus injury, sagittal plane shoulder and elbow angles were extracted from gait recordings of young rats (n = 18), after which rats were sacrificed for bilateral muscle architecture measurements. Musculoskeletal models reflecting animal-specific muscle architecture parameters were used to simulate gait and extract muscle fiber lengths. The preganglionic neurectomy group spent significantly less (p = 0.00116) time in stance and walked with significantly less (p < 0.05) elbow flexion and shoulder protraction in the affected limb than postganglionic neurectomy or control groups. Linear regression revealed no significant linear relationship between passive shoulder external rotation and functional shoulder protraction range of motion. Despite significant restriction in longitudinal muscle growth, normalized functional fiber excursions did not differ significantly between groups. In fact, when superimposed on a normalized force-length curve, neurectomy-impaired muscle fibers (except subscapularis) accessed regions of the curve that overlapped with the control group. Our results suggest the presence of compensatory motor control strategies during locomotion following BPBI. The clinical implications of our findings support emphasis on functional movement analysis in treatment of BPBI, as functional and passive outcomes may differ substantially.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据