Efficient potassium hydroxide promoted P-arylation of aryl halides with diphenylphosphine

A simple synthetic method of triarylphosphine compounds by KOH-promoted P-Arylation reaction of aryl halides with diphenylphosphine is presented. Notably, this transformation could smoothly proceed with high yields under transition-metal-free and mild reaction conditions. In addition, this protocol is valu-able for industrial application due to the convenient operation and readily accessible aromatic halides. A possible explanation of the reaction mechanism was proposed based on the experimental data. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study presents a simple method for synthesizing triarylphosphine compounds through KOH-promoted P-Arylation reaction of aryl halides with diphenylphosphine. The transformation proceeds smoothly with high yields under transition-metal-free and mild conditions, making it valuable for industrial application. The proposed possible explanation of the reaction mechanism is based on experimental data.