期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 21, 页码 14356-14370出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00857
关键词
-
资金
- Syngene
A regioselective 1,2-addition of silyl enol ethers to quinones can now be achieved via a palladium(II) enolate pathway, providing access to cyclohexadienone derivatives. This protocol proceeds under mild reaction conditions without the need for an external ligand or base, and the products have been used as synthetic precursors for fused heteroaryl systems.
In contrast to the conventional 1,4-addition process, regioselective 1,2-addition of silyl enol ethers to quinones can now be achieved via a palladium(II) enolate pathway that provides access to 4-hydroxy-4-(2-oxo-2-arylethyl)cyclohexa-2,5-dien-1-onederivatives. This quinone alkylation protocol proceeds under mild reaction conditions at ambient temperature under open air and does not require either an external ligand for the palladium or the use of a base. Additionally, the cyclohexadienone products have been exploited as synthetic precursors for the construction of fused heteroaryl systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据