期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 23, 页码 16300-16314出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01572
关键词
-
资金
- National Natural Science Foundation of China [21931010]
- National Key R&D Program of China [2017YFA0207302]
The research findings demonstrated that Tf2O/TTBP can be an alternative amide activation system for the direct transformation of both secondary and tertiary amides, generally obtaining higher or comparable yields. Additionally, the combination of Tf2O/TTBP was also effective in promoting various important reactions, leading to concise and high-yield syntheses of natural products.
Ten types of Tf2O/TTBP-mediated amide transformation reactions were investigated. The results showed that compared with pyridine derivatives 2,6-di-tert-butyl-4-methylpyridine (DTBMP) and 2-fluoropyridine (2-F-Pyr.), TTBP can serve as an alternative amide activation system for the direct transformation of both secondary and tertiary amides. For most surveyed examples, higher or comparable yields were generally obtained. In addition, Tf2O/TTBP combination was used to promote the condensation reactions of 2-(tert-butyldimethylsilyloxy)furan (TBSOF) with both tertiary and secondary amides, the one-pot reductive Bischler-Napieralski-type reaction of tertiary lactams, and Movassaghi and Hill's modern version of the Bischler-Napieralski reaction. The value of the Tf2O/TTBP-based methodology was further demonstrated by the concise and high-yielding syntheses of several natural products.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据