4.7 Article

Lithium-Promoted Cycloaddition of Indole-2,3-dienolates and Carbon Disulfide as a One-Pot Route to Thiopyrano[4,3-b]indole-3(5H)-thiones

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Summary: A simple and efficient method has been developed for the synthesis of spiro[indoline-3,4-thiopyrano[2.3-b]indole derivatives through a new mechanistic pathway involving the reaction of thieno[2,3-b]indole-2,3-dione with N-substituted isatilidenes. The synthesized compounds have been screened for antibacterial activity, with the generality of the reaction and mechanistic rationale also presented.

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