期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 14, 页码 9692-9698出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00967
关键词
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资金
- National Natural Science Foundation of China [21625204, 21790330, 21532003, 21971119, 91956000]
- 111 project of the Ministry of Education of China [B06005]
- National Program for Special Support of Eminent Professionals
- Frontiers Science Center for New Organic Matter at Nankai University [63181206]
The highly enantioselective Si-H bond insertion reaction of alpha-aryldiazoacetates catalyzed by chiral spiro dirhodium tetraphosphate was successfully developed, leading to the preparation of various chiral alpha-silyl esters with high yield and excellent enantioselectivity. Even challenging substrates for other chiral dirhodium catalysts showed good results in this reaction, making it one of the few successful applications of chiral dirhodium phosphates in asymmetric catalysis.
A highly enantioselective Si-H bond insertion reaction of alpha-aryldiazoacetates catalyzed by chiral spiro dirhodium tetraphosphate was developed. Various chiral alpha-silyl esters were prepared with high yield (up to 92%) and excellent enantioselectivity (up to >99% ee) through this protocol. It is noteworthy that the 2-substituted aryl diazoacetates, which are challenging substrates for other chiral dirhodium catalysts, also exhibited good results in this reaction. This work represents one of the few successful applications of chiral dirhodium phosphates in asymmetric catalysis.
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