Electro-Oxidative C-N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles

A practical protocol to synthesize 3-substituent-2-(azol-1-yl)indole derivatives has been developed via an electrochemical oxidative cross coupling process under mild conditions. This electro-oxidative C-N bond formation strategy tolerates a range of functional groups and is amenable to gram scale synthesis. Moreover, this method was applied to the late-stage functionalization of bioactive molecules.

Automated summary

A practical protocol for synthesizing 3-substituent-2-(azol-1-yl)indole derivatives has been developed through an electrochemical oxidative cross coupling process. This strategy tolerates a variety of functional groups and is suitable for gram scale synthesis, as well as late-stage functionalization of bioactive molecules.