Palladium-Catalyzed Aryl-Furanylation of Alkenes: Synthesis of Benzofuran-Containing 3,3-Disubstituted Oxindoles

A novel palladium-catalyzed aryl-furanylation of alkenes is described. This protocol provided a straightforward route to the synthesis of various benzofuran-containing 3,3-disubstitutedoxindole derivatives bearing a quarternary carbon center. In the cascade process, one C(sp(2))-O bond, two C(sp(2))C(sp(3)) bonds, an oxindole, and a furan ring are formed in a single chemical operation.

Automated summary

This novel palladium-catalyzed aryl-furanylation of alkenes provides a straightforward route to various benzofuran-containing 3,3-disubstituted oxindole derivatives bearing a quarternary carbon center. In a single chemical operation, one C(sp(2))-O bond, two C(sp(2))C(sp(3)) bonds, an oxindole, and a furan ring are formed in the cascade process.