期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 17, 页码 11361-11369出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00852
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资金
- RFBR [20-3370126]
The method described in this study efficiently synthesizes 2-R-naphtho[2,3-b]thiophene-4,9-diones via a series of reactions starting from 2-bromo-1,4-naphthoquinone and alkynes. The protocol offers mild reaction conditions, good functional group tolerance, and readily available starting materials.
The concise and efficient one-pot synthesis of 2-R-naphtho[2,3-b]thiophene-4,9-diones from 2-bromo-1,4-naphthoquinone and alkynes has been developed. The reaction proceeds through the formation of 2-(R-ethynyl)-1,4-naphthoquinones, which undergo transformation with Na2S2O3 to 2-R-naphtho[2,3-b]thiophene-4,9-diones via C-H sulfuration, accompanied by the formation of the aromatic Bunte salt, followed by its air oxidation and 5-endo-dig cyclization. The protocol is characterized by simplicity, good tolerance for functional groups, relatively mild conditions, and commercially available starting compounds.
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