期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 12, 页码 8437-8447出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00965
关键词
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资金
- National Natural Science Foundation of China [21971174, 21772137]
- PAPD
- Soochow University
An efficient transition-metal-free decarboxylative cyclization of N-arylacrylamides with 2,2-difluoro-2-(phenylthio)acetic acid for the construction of thiodifluoroindoleone derivatives has been described. The strategy features stable and readily available substrates, mild reaction conditions, and transition-metal-free catalysts. This protocol has also been successfully applied to the synthesis of gem-difluoroalkenes found in numerous biologically active compounds.
An efficient transition-metal-free decarboxylative cyclization of N-arylacrylamides with 2,2-difluoro-2-(phenylthio)acetic acid for the construction of thiodifluoroindoleone derivatives is described. This strategy features stable and readily available substrates, mild reaction conditions, and transition-metal-free catalysts. Notably, this protocol has successfully applied to synthesis of gem-difluoroalkenes, which exist in numerous biologically active compounds.
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