期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 12, 页码 8248-8262出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00707
关键词
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资金
- Innovation Fund Denmark [7038-00149B]
- H. Lundbeck A/S
The study presents a synthetic approach for generating a diverse set of Erythrina natural product analogues, as well as the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both of which were found to be potent antagonists of beta 2-containing nAChRs.
Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at beta 2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the beta 2-containing nAChRs.
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