4.7 Article

Metal-Free and Regioselective Synthesis of Functionalized α-Carbolines via [3+3] Annulation of Morita-Baylis-Hillman Acetates of Nitroalkenes with Iminoindolines

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Summary: Carbolines are widely distributed in nature and have diverse biological activities, such as anticancer and antidepressant effects. They are classified into four types based on the position of nitrogen atoms on the pyridine ring. Various synthetic strategies have been developed for each type of carbolines, showing potential in therapeutic applications.

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