Mechanochemical Rearrangements

Molecular rearrangements are a powerful tool for constructing complex structures in an atom- and step-economic manner, translating multistep transformations into an intrinsically more sustainable process. Mechanochemical molecular rearrangements become an even more appealing eco-friendly synthetic approach, especially for preparing active pharmaceutical ingredients (APIs) and natural products. Still in their infancy, rearrangements promoted by mechanochemistry represent a promising approach for chemists to merge molecular diversity and green chemistry perspectives toward more selective and efficient syntheses with a reduced environmental footprint.

Automated summary

Molecular rearrangements using mechanochemistry are a powerful tool to construct complex structures in a sustainable manner, particularly for preparing active pharmaceutical ingredients and natural products. This approach, although still in its early stages, holds promise for chemists to merge molecular diversity and green chemistry perspectives towards more selective and efficient syntheses.