期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 14, 页码 9733-9743出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01075
关键词
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资金
- SERB, DST [ECR/2016/000108]
The Ru-catalyzed reaction provides an economical and simple operational strategy for synthesizing biologically active 1,8-dioxodecahydroacridine derivatives with a wide substrate scope and good tolerance toward various functional groups.
A Ru-catalyzed acceptorless dehydrogenative multi-component reaction has been developed. This reaction offers a cost-effective and simple operational strategy to synthesize biologically active 1,8-dioxodecahydroacridine derivatives. The protocol provides a wide range of substrate scope and various functional groups are also well tolerated under the reaction condition. To shed light on the mechanistic and kinetic study, some controlled experiments and deuterium labeling experiments were executed. A time-dependent product distribution experiment is also presented and the reaction scale-up is performed to highlight the practical utility of this strategy.
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