4.7 Article

Multicomponent Reaction for Diastereoselective Synthesis of Spiro[carbazole-3,4 '-pyrazoles] and Spiro[carbazole-3,4 '-thiazoles]

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 13, 页码 8726-8741

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AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00538

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资金

  1. National Natural Science Foundation of China [21572196, 21871227]
  2. Priority Academic Program Development of Jiangsu Higher Education Institutions [BK2013016]

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The presence of copper sulfate enables the three-component and four-component reactions involving aromatic aldehydes, ethylindole-3-acetate, and various small molecules to proceed efficiently in refluxing toluene, yielding spiro[carbazole-3,4'-pyrazoles] and spiro[carbazole-3,4'-thiazoles] with high diastereoselectivity. The reaction outcomes demonstrate the versatility and potential utility of CuSO4 catalysis in diverse multi-component reactions.
In the presence of copper sulfate, the three-component reaction of aromatic aldehydes, ethylindole-3-acetate and 4-arylidene-5-methyl-2-phenylpyrazol-3-ones, in refluxing toluene afforded spiro[carbazole-3,4'-pyrazoles] in good yields with high diastereoselectivity. More importantly, the similar CuSO4 promoted the four-component reaction of two molecular aromatic aldehydes with ethylindole-3-acetate and 5-methyl-2-phenyl-pyrazol-3-one resulted in 2,4-diarylspiro[carbazole-3,4'-pyrazoles] in satisfactory yields. Additionally, CuSO4 promoted the four-component reaction of two molecular aromatic aldehydes, ethylindole-3-acetate and 2-phenylthiazol-4-one, in refluxing toluene gave 2,4-diarylspiro[carbazole-3,4'-thiazoles] with diastereomeric ratios in the range of 3:1 to 20:1.

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