Cascade Reaction of Tryptamine-Derived Isocyanides with Nitrile Oxides: Construction of Oxazine Fused-Spiroindoline Derivatives

A one-step cascade reaction of tryptamine-derived isocyanides with in situ generated nitrite oxides for the synthesis of fused spiroindolines was described. The desired products could be efficiently synthesized in moderate to good yields (42-87%). The protocol features mild conditions, wide substrate scope, and high efficiency.

Automated summary

A one-step cascade reaction using tryptamine-derived isocyanides and in situ generated nitrite oxides was described for the synthesis of fused spiroindolines, with moderate to good yields (42-87%). The protocol offers mild conditions, wide substrate scope, and high efficiency.