4.7 Article

Cascade Reaction of Tryptamine-Derived Isocyanides with Nitrile Oxides: Construction of Oxazine Fused-Spiroindoline Derivatives

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 18, 页码 12597-12606

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AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01054

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资金

  1. National Natural Science Foundation of China [21772138, 21672157]
  2. project of scientific and technologic infrastructure of Suzhou [SZS201708]
  3. PAPD

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A one-step cascade reaction using tryptamine-derived isocyanides and in situ generated nitrite oxides was described for the synthesis of fused spiroindolines, with moderate to good yields (42-87%). The protocol offers mild conditions, wide substrate scope, and high efficiency.
A one-step cascade reaction of tryptamine-derived isocyanides with in situ generated nitrite oxides for the synthesis of fused spiroindolines was described. The desired products could be efficiently synthesized in moderate to good yields (42-87%). The protocol features mild conditions, wide substrate scope, and high efficiency.

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