期刊
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
卷 47, 期 9, 页码 3107-3118出版社
WILEY
DOI: 10.1111/jog.14883
关键词
birth outcomes; perfluorooctane sulfonic acid; perfluorooctanoic acid; predictors; pregnancy
资金
- Brazil Ministry of Health
- Pan-American Organization of Health-Office Brazil
- Surveillance Health Secretary of the Ministry of Health of Brazil
The study found that maternal age, fish consumption, passive smoking, and the number of rooms in the house were predictors of maternal PFAS levels. However, no significant associations were observed between maternal plasma PFAS concentrations and birth outcomes.
Aim Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent pollutants associated with adverse birth outcomes. This study aimed to identify predictors of blood PFOA and PFOS concentrations in pregnant women and to estimate their associations with birth outcomes in Brazil. Methods We conducted a cross-sectional study with 139 pregnant women enrolled in the pilot study of the Rio Birth Cohort Study on Environmental Exposure and Childhood Development (PIPA Project). Multiple linear regression was used to estimate associations between PFOA and PFOS with maternal predictors and birth outcomes. Results Higher levels of PFOA were observed in women aged 16-19 and 20-39 years, while fish consumption from 0.6 to 2.0 times per week was associated with lower levels of the substance. PFOS levels were higher in women living in houses with up to four rooms but lower in those who reported passive exposure to smoking. Increased newborn length and head circumference were also associated with higher maternal levels of PFOA. Conclusions In our study, age, fish consumption, passive smoking, and the number of rooms in the house were predictors of maternal PFAS levels. However, we did not observe significant associations between maternal plasma PFAS concentrations and birth outcomes.
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