期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 94, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2021.108646
关键词
Cell signaling; Mitochondria; Non-alcoholic fatty liver disease; Nutrition Liver; Nitroalkenes; High fat diet; Mediterranean diet
资金
- ANII-Innovagro [FSA 1 2013 1 12622]
- CSIC-Grupos [536]
- CSIC I+D
- NIH [P01 AG043376, P20 GM109098]
- ANII-Uruguay
The consumption of extra virgin olive oil has been shown to reduce the development of non-alcoholic fatty liver disease (NAFLD), with nitro-fatty acids potentially playing a key role in this benefit. Supplementation with olive oil and nitrite can improve liver mitochondrial function in mice and reduce fat liver accumulation.
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat deposition in the absence of significant alcohol intake. Since extra virgin olive oil (EVOO) reduces fat accumulation, we analyzed the involvement of nitro-fatty acids (NO2-FA) on the beneficial effects of EVOO consumption on NAFLD. Nitro-fatty acids formation was observed during digestion in mice supplemented with EVOO and nitrite. Mice fed with a high-fat diet (HF) pre-sented lower plasma NO2-FA levels than normal chow, and circulating concentrations recovered when the HF diet was supplemented with 10% EVOO plus nitrite. Under NO2-FA formation conditions, liver hemoxygenase-1 expression significantly increased while decreased body weight and fat liver accumulation. Mitochondrial dysfunction plays a central role in the pathogenesis of NAFLD while NO2-FA has been shown to protect from mitochondrial oxidative damage. Accordingly, an improvement of respiratory indexes was observed when mice were supplemented with both EVOO plus nitrite. Liver mitochondrial complexes II and V activities were greater in mice with EVOO supplementation and further improved in the presence of nitrite. Overall, our results strongly suggest a positive correlation between NO2-OA formation from EVOO and the observed improvement of mitochondrial function in NAFLD. The formation of NO2-FA can account for the health benefits associated with EVOO consumption. (C) 2021 Elsevier Inc. All rights reserved.
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