期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 94, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2021.108632
关键词
Natural compound; Nutraceuticals; Plant-derived polyphenols; Respiratory diseases; Tannins; Therapeutic potential
资金
- Ramalingaswami re-entry fellowship [BT/RLF/Re-entry/36/2013]
- Ramalingaswami re-entry fellowship from the Department of Biotechnology (DBT), Government of India
- Indian Council of Medical Research (ICMR), New Delhi, India [45/42/2019-PHA/BMS, 45/03/2018-BMS/PHA/OL]
Respiratory diseases are a major cause of human illness and death worldwide. Phytochemicals, particularly tannins, are being increasingly studied for their beneficial properties in tackling a wide range of non-malignant respiratory diseases. Research has shown that tannins possess protective properties and their mechanistic pathways and clinical trial outcomes are discussed in this review.
Respiratory diseases are the major cause of human illness and death around the world. Despite advances in detection and treatment, very few classes of safe and effective therapy have been introduced to date. At present, phytochemicals are getting more attention because of their diverse beneficial activities and minimal toxicity. Tannins are polyphenolic secondary metabolites with high molecular weights, which are naturally present in a wide variety of fruits, vegetables, cereals, and leguminous seeds. Many tannins are endowed with well-recognized protective properties, such as anti-cancer, anti-microbial, antioxidant, anti-hyperglycemic, and many others. This review summarizes a large body of experimental evidence implicating that tannins are helpful in tackling a wide range of non-malignant respiratory diseases including acute lung injury (ALI), pulmonary fibrosis, asthma, pulmonary hypertension, and chronic obstructive pulmonary disease (COPD). Mechanistic pathways by which various classes of tannins execute their beneficial effects are discussed. In addition, clinical trials and our perspective on future research with tannins are also reviewed. (c) 2021 Elsevier Inc. All rights reserved.
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