期刊
FORENSIC SCIENCE INTERNATIONAL
卷 259, 期 -, 页码 E14-E19出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2015.12.020
关键词
alpha-Pyrrolidinovalerophenone; Pyrrolidinophenone; Designer drug; Gas chromatography-mass spectrometry; General unknown screening
alpha-Pyrrolidinovalerophenone (alpha-PVP) is a synthetic cathinone belonging to the group of second generation'' pyrrolidinophenones that becomes more and more popular as a designer psychostimulant. Here we provide toxicological analytical support for a severe poisoning with alpha-PVP. Serum and urine samples that were sent to our laboratory were subjected to a general unknown screening procedure. The procedure includes immunoassay-based screening of drugs of abuse in serum and systematic toxicological analysis of urine and serum after neutral and basic liquid-liquid extraction followed by gas chromatography-mass spectrometry (GC-MS). Whereas the immunoassay delivered negative results, analyzing the urine sample by GC-MS in full scan mode disclosed the presence of alpha-PVP and its metabolites alpha-(2 ''-oxo-pyrrolidino)valerophenone (2 ''-oxo-alpha-PVP) and 1-phenyl-2-(pyrrolidin-1-yl) pentan-1-ol (OH-alpha-PVP). In the acetylated urine sample we found additionally N,N-bis-dealkyl-PVP. In serum, alpha-PVP could be detected after solid phase extraction and a concentration of 29 ng/mL was determined. Other forensic relevant substances were not detected. The presented data can explain the psychotic symptoms and behavioural pattern of the subject after abuse of alpha-PVP, leading to a clinical condition similar to excited delirium syndrome. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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