期刊
JOURNAL OF NEUROCHEMISTRY
卷 158, 期 3, 页码 779-797出版社
WILEY
DOI: 10.1111/jnc.15449
关键词
alpha synuclein; diffusion kurtosis imaging; MRI; Parkinson; rotenone; s disease; tract-based spatial statistics
资金
- SoMoPro II program
- People Programme (Marie Curie action) of the Seventh Framework Programme of the EU [291782]
- South-Moravian Region
- CEITEC 2020 [LQ1601]
The study demonstrates the utility of diffusion kurtosis imaging in detecting progressive microstructural changes in different brain regions of mice with a Parkinson's Disease-like pathology, showing that pathologic changes can self-perpetuate and intensify within the central nervous system after exposure to rotenone for 2 months.
Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (SN) already died, and the first motor symptoms appear. Therefore, tools enabling the early diagnosis of PD are essential to identify early-stage PD patients in which neuroprotective treatments could have a significant impact. Here, we test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone, a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging. Our results show that DKI, especially kurtosis, can detect the progression of pathology-associated changes throughout the CNS. Increases in mean kurtosis were first observed in the dorsal motor nucleus of the vagus (DMV) after 2 months of exposure to rotenone and before the loss of dopaminergic neurons in the SN occurred. Remarkably, we also show that limited exposure to rotenone for 2 months is enough to trigger the progression of the disease in the absence of the environmental toxin, thus suggesting that once the first pathological changes in one region appear, they can self-perpetuate and progress within the CNS. Overall, our results show that DKI can be a useful radiological marker for the early detection and monitoring of PD pathology progression in patients with the potential to improve the clinical diagnosis and the development of neuroprotective treatments.
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