期刊
JOURNAL OF NEURAL TRANSMISSION
卷 128, 期 8, 页码 1169-1175出版社
SPRINGER WIEN
DOI: 10.1007/s00702-021-02381-5
关键词
Deep brain stimulation; EEG biomarkers; Local field potentials; Movement disorders
资金
- Czech science foundation [GACR 21-25953S]
- Czech health research council AZV [NU21-04-00445]
This article discusses the relationship between neurological diseases and oscillatory dysfunctions, highlighting the importance of electrophysiological biomarkers used in deep brain stimulation therapy, especially in the field of movement disorders.
Several neurological diseases are accompanied by rhythmic oscillatory dysfunctions in various frequency ranges and disturbed cross-frequency relationships on regional, interregional, and whole brain levels. Knowledge of these disease-specific oscillopathies is important mainly in the context of deep brain stimulation (DBS) therapy. Electrophysiological biomarkers have been used as input signals for adaptive DBS (aDBS) as well as preoperative outcome predictors. As movement disorders, particularly Parkinson's disease (PD), are among the most frequent DBS indications, the current research of DBS is the most advanced in the movement disorders field. We reviewed the literature published mainly between 2010 and 2020 to identify the most important findings concerning the current evolution of electrophysiological biomarkers in DBS and to address future challenges for prospective research.
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