期刊
JOURNAL OF NATURAL PRODUCTS
卷 84, 期 8, 页码 2380-2384出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c00120
关键词
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资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [Li844/11-1, INST 160/620-1]
- National Natural Science Foundation of China [31861133004]
- China Scholarship Council [201806220101, 201507565006, 201607565014]
Expression of a nonribosomal peptide synthetase-nonreducing polyketide synthase hybrid gene pcr10109 from Penicillium crustosum PRB-2 in Aspergillus nidulans led to the accumulation of 4-hydroxy-6-(4-hydroxyphenyl)-alpha-pyrone (1). Adding para-hydroxybenzoic acid into the medium in which the overexpressing mutant is growing increased the product yield up to 5-fold. This strategy could be helpful for heterologous gene expression experiments requiring special substrates for product formation.
Expression of a nonribosomal peptide synthetase-nonreducing polyketide synthase hybrid gene pcr10109 from Penicillium crustosum PRB-2 in Aspergillus nidulans led to the accumulation of 4-hydroxy-6-(4-hydroxyphenyl)-alpha-pyrone (1). Adding para-hydroxybenzoic acid into the medium in which the overexpressing mutant is growing increased the product yield up to 5-fold. This strategy could be helpful for heterologous gene expression experiments requiring special substrates for product formation.
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