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Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides

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Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides

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Summary: Two phenylpropanoid-conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin (2), isolated from Morinda morindoides leaves showed potential anti-malarial activity. Known compounds molucidin (3) and prismatomerin (4) exhibited strong activity, while new iridoids 1 and 2 and pinoresinol (5) displayed moderate activity without cytotoxicity. These compounds may serve as promising lead compounds for anti-malarial drugs.

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