Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis

In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 mu g/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study describes the synthesis, characterization, and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes. The compounds were characterized using various analytical techniques, and displayed promising activities against M. tuberculosis, including multidrug-resistant clinical strains. The cytotoxic activity assays revealed high selectivity indexes for all compounds over MRC-5 cells.