期刊
JOURNAL OF MOLECULAR NEUROSCIENCE
卷 71, 期 12, 页码 2433-2440出版社
SPRINGERNATURE
DOI: 10.1007/s12031-021-01859-x
关键词
Spinal cord injury; Zinc; Neuron; Inflammation; Autophagy; Oxidative stress
资金
- National Natural Science Foundation of China (NSFC) [81871556, 82072165]
- Liaoning Revitalization Talents Program [XLYC1902108]
Zinc plays a crucial role in predicting the prognosis and treating spinal cord injury by inhibiting inflammation, regulating autophagy, and reducing oxidative stress. However, excessive zinc can cause damage to neurons.
Spinal cord injury is a serious disease of the central nervous system, but there is no effective treatment. And zinc is an essential nutrient for human body and participates in many physiological processes, such as immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. This article mainly summarizes that zinc could predict the prognosis and treat the spinal cord injury. Especially, zinc could help to inhibit inflammation, regulate autophagy, and reduce oxidative stress. However, excessive zinc will damage neurons.
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