Fabrication and characterization of TPP-β-cyclodextrin/chitosan supramolecular nanoparticles for delivery dual bioactive compounds

The TPP-beta-cyclodextrin/chitosan (TPP-beta-CD/CS) nanoparticles loading with curcumin (Cur) and vitamin C (Vc) was prepared via controllable self-assembly. The cross-linking reaction between TPP-beta-CD and CS, and co-encapsulation of Cur and Vc in TPP-beta-CD/CS nanoparticles were confirmed by the fouriertransform infrared (FTIR), UV-Vis (UV), X-ray diffraction (XRD), atomic force microscope (AFM), and particle size analyzer. The results of stability and antioxidant activity indicated that co-encapsulation not only enhanced the chemical stability of Cur and Vc, but also improved antioxidant properties compared with the active ingredients used alone. Release kinetic fitted by Ritger-Peppas model revealed that the release of dual active ingredients were mainly dominated by Fickian diffusion in pH 1.2, while followed non-Fickian or anomalous diffusion in pH 7.4. Furthermore, the two-dimensional UV correlation spectroscopy (2D-UV-COS) confirmed that the release rate of Cur was faster than that of Vc during co-delivery, which helps to precisely elucidate the synergistic nutraceuticals effect of each active ingredient. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

The study prepared TPP-beta-cyclodextrin/chitosan nanoparticles loaded with curcumin and vitamin C through controllable self-assembly, which showed enhanced chemical stability and antioxidant properties compared to individual ingredients. Release kinetics varied under different pH conditions, with Fickian diffusion dominating at pH 1.2 and non-Fickian or anomalous diffusion at pH 7.4. Additionally, the release rate of curcumin was faster than that of vitamin C, confirming the synergistic nutraceutical effect of each active ingredient.