4.7 Article

Charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part III: A green protocol for facile synthesis of complexes with TCNQ, DDQ, and TFQ acceptors

期刊

JOURNAL OF MOLECULAR LIQUIDS
卷 335, 期 -, 页码 -

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ELSEVIER
DOI: 10.1016/j.molliq.2021.116250

关键词

Charge-transfer; Azithromycin; TCNQ; DDQ; TFQ; Eco-friendly; SARS-CoV-2; COVID-19

资金

  1. Taif University, Taif, Saudi Arabia [TURSP-2020/02]

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Researchers synthesized charge-transfer complexes containing azithromycin and three pi-acceptors using an efficient, simple, clean, and eco-friendly method. The study found that this method is environmentally friendly, avoids hazardous organic solvents, and generates the desired complexes with excellent yield.
Investigating the chemical properties of molecules used to combat the COVID-19 pandemic is of vital and pressing importance. In continuation of works aimed to explore the charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat COVID-19, the disease resulting from infection with the novel SARS-CoV-2 virus, in this work, a highly efficient, simple, clean, and eco-friendly protocol was used for the facile synthesis of charge-transfer complexes (CTCs) containing azithromycin and three pi-acceptors: 7,7,8,8-tetracyanoquinodimethane (TCNQ), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), and tetrafluoro-1,4-benzoquinone (TFQ). This protocol involves grinding bulk azithromycin as the donor (D) with the investigated acceptors at a 1:1 M ratio at room temperature without any solvent. We found that this protocol is environmentally benign, avoids hazardous organic solvents, and generates the desired CTCs with excellent yield (92-95%) in a straightforward means. (C) 2021 Elsevier B.V. All rights reserved.

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