期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 338, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molliq.2021.116643
关键词
Pluronic P85; Pluronic P123, Micelle; Lavender oil, Antimicrobial; Anticancer
This study explores the solubilization characteristics of Lavender essential oil in Pluronic P85 micellar systems, revealing its ability to induce structural transitions in micelles, exhibit anticancer and antimicrobial properties, and demonstrate the existence of upper and lower cloud points.
Importance of pluronic P85 as carrier for drugs arises due to its ability to sensitize cell membranes for delivery of drugs across multi drug resistant cancer cells and blood brain barrier. It is thus necessary to understand how lipophilic drugs and phytochemicals influence its self-assembly characteristics and how the therapeutic properties of these lipophiles are modulated upon encapsulation in P85 micelles. We have investigated solubilization characteristics of Lavender essential oil (LO) in P85 and P85-P123 micellar systems and studied the associated structural and therapeutic properties by DLS, SANS, viscosity, ITC, antimicrobial and in vitro cancer cell viability studies. We observed that LO induces micellar structural transitions in aqueous P85 and P85-P123 systems leading to the formations of worm like micelles and vesicles. LO solubilized systems exhibit anticancer and antimicrobial properties, and show existence of double cloud points namely, upper and lower cloud points (UCP & LCP). A spherical-to-elliptical micellar structural transition is observed in these LO solubilized systems upon cooling down to LCP, which is unusual and not reported hitherto in aqueous pluronic systems. The observed results show how essential oils can influence the self-assembly characteristics of P85 based micellar systems and how their therapeutic properties are manifested under micellar encapsulation. (C) 2021 Elsevier B.V. All rights reserved.
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