A new correlative model to simulate the solubility of drugs in mono-solvent systems at various temperatures

A simple model is proposed for correlating the solubility of a given drug in different mono-solvents at various temperatures. The model is based on the well-known van't Hoff equation and employs a combination of Abraham, Hansen and Catalan parameters as variables representing the drug-solvent interactions in the solutions. The proposed model correlates the solubility of each drug in different mono-solvents at various temperatures. The accuracy of the model for correlating the data was investigated by calculating the mean percentage deviation of the back-calculated data and the corresponding experimental values. Thirty solubility data sets were collected randomly from the recently published articles. The obtained results are promising and the novel model could be recommended for further investigations. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

A simple model based on the van't Hoff equation and a combination of Abraham, Hansen, and Catalan parameters is proposed to correlate the solubility of drugs in different mono-solvents at various temperatures. The model shows promising results in correlating the data, and further investigations are recommended based on the accuracy of the model.