期刊
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
卷 31, 期 8, 页码 1134-1143出版社
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.2102.02032
关键词
Benign prostatic hyperplasia; Enterococcus faecalis; heat-killed microorganism
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2020R1A2C1014798]
The study investigated the inhibitory effect of both heat-killed and live Enterococcus faecalis on benign prostatic hyperplasia, showing a reduction in prostate weight and histological changes due to treatment. This indicates that Enterococcus faecalis may be a potential food additive candidate for addressing BPH.
In the present study, we investigated the inhibitory effect of heat-killed Enterococcus faecalis (E. faecalis) and live E. faecalis on benign prostatic hyperplasia (BPH). The BPH rat model was established by administering male rats with testosterone propionate (TP, 5 mg/kg, in corn oil) via subcutaneous injections daily for four weeks after castration. The rats were divided into five groups: Con, corn oil-injected (s.c.) + DW administration; BPH, TP (5 mg/kg, s.c.) + DW administration; BPH+K_EF, TP (5 mg/kg, s.c.) + heat-killed E. faecalis (7.5 x 10(12) CFU/g, 2.21 mg/kg) administration; BPH+L EF, TP (5 mg/kg, s.c.) + live E. faecalis (1 x 10(11) CFU/g, 166 mg/kg) administration; BPH+Fi, TP (5 mg/kg, s.c.) + finasteride (1 mg/kg) administration. In both of BPH+K_EF and BPH+L_EF groups, the prostate weight decreased and histological changes due to TP treatment recovered to the level of the Con group. Both of these groups also showed regulation of androgen-signaling factors, growth factors, and apoptosis-related factors in prostate tissue. E. faecalis exhibited an inhibitory effect on benign prostatic hyperplasia, and even heat-killed E. faecalis showed similar efficacy on the live cells in the BPH rat model. As the first investigation into the effect of heat-killed and live E. faecalis on BPH, our study suggests that heat-killed E. faecalis might be a food additive candidate for use in various foods, regardless of heat processing.
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