The Future of Medicinal Chemistry, PROTAC, and Undruggable Drug Targets

WRD5 is a promising target for anticancer drug discovery. In addition, it plays a vital role in epigenetic regulation. Since biological inactivation of WRD5 is difficult to reach via classical approach, PROTACs (Proteolysis Targeting Chimeras) are offering a new option. In a study, published in this journal, new WRD5 targeting PROTACS are introduced. These new compounds, which are also active in cells, make it possible to evaluate the value of WRD5 as a drug target.

Automated summary

WRD5 is a promising target for anticancer drug discovery and plays a vital role in epigenetic regulation. PROTACs offer a new option for biological inactivation of WRD5, and new WRD5 targeting PROTACs introduced in a study make it possible to evaluate WRD5 as a drug target.