4.7 Article

Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Modified Hypoxia-Inducible Factor Expression in CD8+ T Cells Increases Antitumor Efficacy

Pedro Velica et al.

Summary: By ectopically expressing the HIF transcription factor in CD8(+) T cells, this study demonstrated an enhanced antitumor efficacy against tumor targets. A specific mutation in HIF2 alpha showed the most effective antitumor T cell response, suggesting a potential strategy to increase therapeutic efficacy of CD8(+) T cells.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Chemistry, Medicinal

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat

William D. Figg et al.

Summary: Researchers have discovered the crystal structures of Molidustat and IOX4 complexed with PHD2, revealing their binding modes and the mechanism of action at the active site.

CHEMMEDCHEM (2021)

Article Biochemistry & Molecular Biology

FIH-1 engages novel binding partners to positively influence epithelial proliferation via p63

Nihal Kaplan et al.

FASEB JOURNAL (2020)

Article Biochemistry & Molecular Biology

HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity

Pascale Sulser et al.

FASEB JOURNAL (2020)

Article Chemistry, Multidisciplinary

Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation

Carmen Domene et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

A human protein hydroxylase that accepts D-residues

Hwanho Choi et al.

COMMUNICATIONS CHEMISTRY (2020)

Article Pharmacology & Pharmacy

Vadadustat: First Approval

Anthony Markham

Article Pharmacology & Pharmacy

Daprodustat: First Approval

Sohita Dhillon

Article Biochemistry & Molecular Biology

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

Tongri Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Review Oncology

2-Oxoglutarate-dependent dioxygenases in cancer

Julie-Aurore Losman et al.

NATURE REVIEWS CANCER (2020)

Article Pharmacology & Pharmacy

Roxadustat: First Global Approval

Sohita Dhillon

Article Multidisciplinary Sciences

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Michael Batie et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

Md Saiful Islam et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1

Christina Pickel et al.

REDOX BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Radioprotective Activity and Preliminary Mechanisms of N-oxalyl-d-phenylalanine (NOFD) In Vitro

Yuanyuan Meng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Hepatic PHD2/HIF-1 axis is involved in postexercise systemic energy homeostasis

Beibei Luo et al.

FASEB JOURNAL (2018)

Article Biochemistry & Molecular Biology

Investigations on the role of a solvent tunnel in the α-ketoglutarate dependent oxygenase factor inhibiting HIF (FIH)

Vanessa D. Chaplin et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2018)

Article Neurosciences

Folic Acid Exerts Post-Ischemic Neuroprotection In Vitro Through HIF-1 Stabilization

Charles K. Davis et al.

MOLECULAR NEUROBIOLOGY (2018)

Review Biochemistry & Molecular Biology

2-Oxoglutarate-Dependent Oxygenases

Md. Saiful Islam et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Chemistry, Multidisciplinary

Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis

Louise J. Walport et al.

CHEMICAL RECORD (2018)

Article Chemistry, Multidisciplinary

O2 Activation by Nonheme FeII α-Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH

Shyam R. Iyer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Oncology

New horizons in hypoxia signaling pathways

Christopher W. Pugh et al.

EXPERIMENTAL CELL RESEARCH (2017)

Article Biochemistry & Molecular Biology

The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation

John A. Hangasky et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2017)

Review Biochemistry & Molecular Biology

The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks

Mircea Ivan et al.

MOLECULAR CELL (2017)

Article Chemistry, Multidisciplinary

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Tzu-Lan Yeh et al.

CHEMICAL SCIENCE (2017)

Article Multidisciplinary Sciences

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Akane Kawamura et al.

NATURE COMMUNICATIONS (2017)

Review Chemistry, Medicinal

Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential

Yagnesh Nagarajan et al.

PHARMACEUTICALS (2017)

Review Biochemistry & Molecular Biology

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB

Laura D'Ignazio et al.

BIOMEDICINES (2017)

Article Biochemistry & Molecular Biology

Substrate Promotes Productive Gas Binding in the α-Ketoglutarate-Dependent Oxygenase FIH

Cornelius Y. Taabazuing et al.

BIOCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Structure-function relationships of human JmjC oxygenases - demethylases versus hydroxylases

Suzana Markolovic et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Mun Chiang Chan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Medicine, Research & Experimental

Hypoxia-dependent regulation of inflammatory pathways in immune cells

Cormac T. Taylor et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Chemistry, Medicinal

Recent Progress in Histone Demethylase Inhibitors

Tom E. McAllister et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

Carsten C. Scholz et al.

PLOS BIOLOGY (2016)

Article Endocrinology & Metabolism

Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta

Sruthi Alahari et al.

ENDOCRINOLOGY (2015)

Article Biochemistry & Molecular Biology

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival

Serafim Kiriakidis et al.

FASEB JOURNAL (2015)

Article Biochemistry & Molecular Biology

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor

Hanna Tarhonskaya et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel

Sarah Karttunen et al.

JOURNAL OF CELL SCIENCE (2015)

Article Cell Biology

Global microRNA depletion suppresses tumor angiogenesis

Sidi Chen et al.

GENES & DEVELOPMENT (2014)

Article Chemistry, Multidisciplinary

Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor

Ming Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Chemistry, Medicinal

Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors

Ivanhoe K. H. Leung et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

Spectroscopic Studies of the Mononuclear Non-Heme FeII Enzyme FIH: Second-Sphere Contributions to Reactivity

Kenneth M. Light et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Chemistry, Multidisciplinary

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

Richard J. Hopkinson et al.

CHEMICAL SCIENCE (2013)

Article Biochemistry & Molecular Biology

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Norma Masson et al.

EMBO REPORTS (2012)

Article Chemistry, Medicinal

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Nathan R. Rose et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Neurosciences

Expressions of hypoxic stress sensor proteins after transient cerebral ischemia in mice

Jingwei Shang et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2012)

Review Rheumatology

Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis

Sofia Konisti et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Review Chemistry, Multidisciplinary

Inhibition of 2-oxoglutarate dependent oxygenases

Nathan R. Rose et al.

CHEMICAL SOCIETY REVIEWS (2011)

Article Biochemistry & Molecular Biology

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Rasheduzzaman Chowdhury et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

Ya-Min Tian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Chemistry, Medicinal

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

Ana Conejo-Garcia et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Biochemistry & Molecular Biology

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Emily Flashman et al.

FEBS JOURNAL (2010)

Article Biochemistry & Molecular Biology

Crystal structures of human FIH-1 in complex with quinol family inhibitors

Hyunjin Moon et al.

MOLECULES AND CELLS (2010)

Article Chemistry, Medicinal

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

Mark D. Rosen et al.

ACS MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Multidisciplinary

Evidence for a Stereoelectronic Effect in Human Oxygen Sensing

Christoph Loenarz et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Medicine, Research & Experimental

FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins

Matthew E. Cockman et al.

HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY (2009)

Article Biochemistry & Molecular Biology

Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)

Sarah E. Wilkins et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Asparaginyl β-Hydroxylation of Proteins Containing Ankyrin Repeat Domains Influences Their Stability and Function

Adam P. Hardy et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

Rasheduzzaman Chowdhury et al.

STRUCTURE (2009)

Review Biochemistry & Molecular Biology

Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway

William G. Kaelin et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Xiaofeng Zheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

ASB4 is a Hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism

James E. Ferguson et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Asparaginyl hydroxylation of the notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

Mathew L. Coleman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Dominic Ehrismann et al.

BIOCHEMICAL JOURNAL (2007)

Article Multidisciplinary Sciences

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Matthew E. Cockman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Cellular oxygen sensing:: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Michael A. McDonough et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Oncology

ASPPs and cancer

G Trigiante et al.

NATURE REVIEWS CANCER (2006)

Review Cell Biology

Notch signalling: a simple pathway becomes complex

Sarah J. Bray

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

LA McNeill et al.

MOLECULAR BIOSYSTEMS (2005)

Article Chemistry, Multidisciplinary

Selective inhibition of factor inhibiting hypoxia-inducible factor

MA McDonough et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Biochemical Research Methods

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases

LA McNeill et al.

ANALYTICAL BIOCHEMISTRY (2005)

Review Cell Biology

Oxygen sensing by HIF hydroxylases

CJ Schofield et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

M Hirsilä et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

C Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α

JM Elkins et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

CE Dann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch

D Lando et al.

SCIENCE (2002)