4.7 Article

Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery

期刊

JOURNAL OF MEDICINAL CHEMISTRY
卷 64, 期 16, 页码 11798-11815

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.1c00579

关键词

-

资金

  1. National Natural Science Foundation of China [81922064, 81874290, 81903502]
  2. Sichuan Science and Technology Program [2020YJ0091]
  3. China Postdoctoral Science Foundation [2020M673268]
  4. Health Commission of Sichuan Province [20PJ002]

向作者/读者索取更多资源

Epigenetic modifications have been shown to regulate autophagy and the expression of tumor-associated genes, promoting tumor progression. Targeting autophagy with emerging epigenetic drugs is a promising therapeutic strategy for tumors.
Existing evidence has demonstrated that epigenetic modifications (including DNA methylation, histone modifications, and microRNAs), which are associated with the occurrence and development of tumors, can directly or indirectly regulate autophagy. In particular, nuclear events induced by several epigenetic regulators can regulate the autophagic process and expression levels of tumor-associated genes, thereby promoting tumor progression. Tumor-associated microRNAs, including oncogenic and tumor-suppressive microRNAs, are of great significance to autophagy during tumor progression. Targeting autophagy with emerging epigenetic drugs is expected to be a promising therapeutic strategy for human tumors. From this perspective, we aim to summarize the role of epigenetic modification in the autophagic process and the underlying molecular mechanisms of tumorigenesis. Furthermore, the regulatory efficacy of epigenetic drugs on the autophagic process in tumors is also summarized. This perspective may provide a theoretical basis for the combined treatment of epigenetic drugs/autophagy mediators in tumors.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据