4.7 Article

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Practical application of ligand efficiency metrics in lead optimisation

James S. Scott et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Review Chemistry, Multidisciplinary

Structure-based design of targeted covalent inhibitors

Richard Lonsdale et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Medicinal

Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations

Robert J. Young et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase

Nicole Blaquiere et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100

Amanda J. Fusco et al.

SCIENCE SIGNALING (2016)

Article Biochemistry & Molecular Biology

The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100

Amanda J. Fusco et al.

SCIENCE SIGNALING (2016)

Review Biochemistry & Molecular Biology

The IκB kinase complex in NF-κB regulation and beyond

Michael Hinz et al.

EMBO REPORTS (2014)

Article Biotechnology & Applied Microbiology

The role of ligand efficiency metrics in drug discovery

Andrew L. Hopkins et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

Jinsong Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Chemistry, Medicinal

Free Energy Calculations by the Molecular Mechanics Poisson-Boltzmann Surface Area Method

Nadine Homeyer et al.

MOLECULAR INFORMATICS (2012)

Article Chemistry, Medicinal

Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis

Kyung-Hee Kim et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Cell Biology

The NF-κB Family of Transcription Factors and Its Regulation

Andrea Oeckinghaus et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

Article Biochemical Research Methods

Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values

Ben-Fillippo Krippendorff et al.

JOURNAL OF BIOMOLECULAR SCREENING (2009)