4.7 Article

Update on the Development of MNK Inhibitors as Therapeutic Agents

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Jianling Xie et al.

Summary: This study uncovers a novel feedback loop in which mTORC1 represses MNK2 activity and oncogenic signaling through eIF4E phosphorylation, providing insights into the reciprocal regulation of these two oncogenic pathways.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

Antisense Oligonucleotides As Potential Therapeutics for Type 2 Diabetes

Suxiang Chen et al.

Summary: Type 2 diabetes is a chronic metabolic disorder characterized by persistent hyperglycemia. Antisense oligonucleotide has attracted attention for its ability to downregulate disease-causing genes. Several antisense agents have been approved for treating various human diseases, including genetic disorders.

NUCLEIC ACID THERAPEUTICS (2021)

Review Pharmacology & Pharmacy

Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain

Muhammad Saad Yousuf et al.

Summary: Translation dysregulation is recognized as a characteristic of many diseases, including chronic pain. Current treatments for chronic pain are not effective and have adverse effects, necessitating the development of novel approaches. Pharmacologically targeting specific translation regulation mechanisms may offer promising new treatments for chronic pain disorders by reversing key neuronal phenotypic changes.

PHARMACOLOGICAL REVIEWS (2021)

Article Pharmacology & Pharmacy

Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E

Ram Kumar et al.

Summary: Emetine has been shown to have antiviral effects against SARS-CoV-2 and infectious bronchitis virus by interfering with viral RNA synthesis and disrupting its binding with cellular proteins. Further research on emetine as a potential treatment for COVID-19 is warranted.

ANTIVIRAL RESEARCH (2021)

Article Oncology

ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation

Hui-er Zhu et al.

Summary: The study demonstrates that ESCO2 promotes proliferation and metastasis of LUAD cells through metabolic reprogramming both in vitro and in vivo. Mechanistically, ESCO2 inhibits hnRNPA1 nuclear translocation, leading to increased binding of hnRNPA1 to the intronic sequences flanking exon 9 of PKM mRNA, ultimately inhibiting PKM1 isoform formation and inducing PKM2 isoform formation.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

Xin-Yu Ke et al.

Summary: Depletion of MNK1/2 suppresses growth of soft tissue sarcoma cells, and a novel MNK inhibitor ETC-168 shows significant antiproliferative efficacy. Combination of ETC-168 with MCL1 inhibitor exerts synergistic antiproliferative activity against STS cells. This study highlights the potential clinical translation of MNK inhibitors for the treatment of soft tissue sarcoma.

ONCOGENE (2021)

Article Biochemistry & Molecular Biology

Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation

Joseph-Patrick W. E. Clarke et al.

Summary: The study demonstrates that mutations in the A1 gene result in cytoplasmic mislocalization of A1 protein, altered cluster dynamics, and enhanced stress granule formation. These findings support the hypothesis that dysfunction of A1 may exacerbate neurodegeneration in multiple sclerosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Topography of transcriptionally active chromatin in glioblastoma

Liang Xu et al.

Summary: This study investigates the role of enhancer landscapes in governing transcriptional diversity and subtype identity in GBM, uncovering previously unrecognized layers of intertumor heterogeneity. The research also reveals the topographies of transcriptional enhancers and core regulatory circuitries in four molecular subtypes of primary tumors, as well as the core oncogenic dependency on super-enhancer-driven factors in GBM. The findings provide insights into molecular classification, pathogenesis, and therapeutic interventions for GBM through profiling of transcriptional enhancers.

SCIENCE ADVANCES (2021)

Review Biochemistry & Molecular Biology

A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease

Joseph P. Clarke et al.

Summary: Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a conserved protein involved in various cellular activities, with potential dysregulation in diseases. Studies have found that dysfunction of hnRNP A1 may contribute to the pathogenesis of neurodegenerative diseases, although the specific mechanisms are still under investigation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Chemistry, Medicinal

Progress in developing MNK inhibitors

Xin Jin et al.

Summary: MNKs phosphorylate eIF4E, playing a crucial role in cancer and metabolic diseases. Inhibitors of MNKs can be used for the treatment of various cancers, including solid tumors and leukemia.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Pharmacology & Pharmacy

Mnk inhibitors: a patent review

Ahmed M. Abdelaziz et al.

Summary: The alteration of mRNA translation plays a crucial role in defining cellular proteome changes, with efforts in developing novel Mnk inhibitors yielding successful results in the pharmaceutical industry. The pyridone-aminal scaffold, including molecules like Tomivosertib (eFT508), has shown significant activity against various cancers.

PHARMACEUTICAL PATENT ANALYST (2021)

Article Medicine, Research & Experimental

First-in-Human, Healthy Volunteers Integrated Protocol of ETC-206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug

Vincenzo Teneggi et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

Article Chemistry, Medicinal

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2

Jacek Kwiatkowski et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Nicotinamide-Ponatinib Analogues as Potent Anti-CML and Anti-AML Compounds

Elizabeth Larocque et al.

ACS OMEGA (2020)

Review Biochemistry & Molecular Biology

Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer

Celia Pinto-Diez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Endocrinology & Metabolism

Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity

Lauren Y. Sandeman et al.

MOLECULAR METABOLISM (2020)

Article Multidisciplinary Sciences

Rescue of oxytocin response and social behaviour in a mouse model of autism

Hanna Hornberg et al.

NATURE (2020)

Article Plant Sciences

Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia

Liang-Chieh Chen et al.

JOURNAL OF NATURAL PRODUCTS (2020)

Editorial Material Biotechnology & Applied Microbiology

Targeting translation

Katharine H. Wrighton

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Chemistry, Medicinal

A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions

Erin E. Gallagher et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Medicine, Research & Experimental

Therapeutic Antisense Oligonucleotides Are Coming of Age

C. Frank Bennett

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

Article Medicine, General & Internal

Inhibiting MNK Selectively Targets Cervical Cancer via Suppressing eIF4E-Mediated β-Catenin Activation

Weijia Zhang et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2019)

Article Chemistry, Medicinal

Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a] pyridine]-1',5'-dione derivatives as Mnk inhibitors

Ahmed M. Abdelaziz et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Article Biochemistry & Molecular Biology

Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening

Rama K. Mishra et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

Article Chemistry, Medicinal

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

Xin Jin et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Clinical Neurology

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

Carlo Rinaldi et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Chemistry, Medicinal

Development of the first small molecule histone deacetylase 6 (HDAC6) degraders

Ka Yang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Chemistry, Medicinal

Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK)

Chengwei Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Phthalimide conjugations for the degradation of oncogenic PI3K

Wenlu Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Adelajda Zorba et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Argel Aguilar-Valles et al.

NATURE COMMUNICATIONS (2018)

Article Biochemical Research Methods

A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1

Yumi Matsui et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2018)

Review Oncology

eIF4E Phosphorylation in Prostate Cancer

Leandro S. D'Abronzo et al.

NEOPLASIA (2018)

Review Genetics & Heredity

The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders

Ines S. Amorim et al.

FRONTIERS IN GENETICS (2018)

Review Genetics & Heredity

eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity

Sonali Uttam et al.

FRONTIERS IN GENETICS (2018)

Review Chemistry, Medicinal

Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers

Ella Lineham et al.

FUTURE MEDICINAL CHEMISTRY (2017)

Article Multidisciplinary Sciences

Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation

Brian C. Avanzino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Multidisciplinary

Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases

Srinivasaraghavan Kannan et al.

ACS OMEGA (2017)

Article Chemistry, Multidisciplinary

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)

Caroline M. Robb et al.

CHEMICAL COMMUNICATIONS (2017)

Article Chemistry, Medicinal

Unveiling new chemical scaffolds as Mnk inhibitors

Sarah Diab et al.

FUTURE MEDICINAL CHEMISTRY (2016)

Article Oncology

Glioblastoma: Overview of Disease and Treatment

Mary Elizabeth Davis

CLINICAL JOURNAL OF ONCOLOGY NURSING (2016)

Article Biochemistry & Molecular Biology

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding

James E. Beggs et al.

BIOCHEMICAL JOURNAL (2015)

Article Biochemistry & Molecular Biology

Differential Requirements for eIF4E Dose in Normal Development and Cancer

Morgan L. Truitt et al.

Review Oncology

Nonsurgical treatment of recurrent glioblastoma

O. Gallego

CURRENT ONCOLOGY (2015)

Article Chemistry, Medicinal

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

Theodosia Teo et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery

Malika Kumarasiri et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Srinivasaraghavan Kannan et al.

BIOCHEMISTRY (2015)

Article Pharmacology & Pharmacy

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2

Sunita K. C. Basnet et al.

MOLECULAR PHARMACOLOGY (2015)

Review Oncology

Epidemiologic and Molecular Prognostic Review of Glioblastoma

Jigisha P. Thakkar et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

Review Biochemistry & Molecular Biology

MAP Kinase-Interacting Kinases-Emerging Targets against Cancer

Sarah Diab et al.

CHEMISTRY & BIOLOGY (2014)

Review Neurosciences

Synaptic proteins and receptors defects in autism spectrum disorders

Jianling Chen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Review Behavioral Sciences

Autism genetics

Antonio M. Persico et al.

BEHAVIOURAL BRAIN RESEARCH (2013)

Review Biochemistry & Molecular Biology

hnRNP A1: The Swiss Army Knife of Gene Expression

Jacques Jean-Philippe et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Multidisciplinary Sciences

Autism-related deficits via dysregulated eIF4E-dependent translational control

Christos G. Gkogkas et al.

NATURE (2013)

Article Multidisciplinary Sciences

Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Sharon Lim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Chemistry, Medicinal

Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

Yan Jia et al.

MEDICINAL RESEARCH REVIEWS (2012)

Article Chemistry, Medicinal

Exploring Aigialomycin D and Its Analogues as Protein Kinase Inhibitors for Cancer Targets

Jin Xu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2011)

Article Biochemistry & Molecular Biology

Sumoylation of eIF4E activates mRNA translation

Xiang Xu et al.

EMBO REPORTS (2010)

Article Biochemistry & Molecular Biology

HDAC2 Promotes eIF4E Sumoylation and Activates mRNA Translation Gene Specifically

Xiang Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

Luc Furic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

eIF4E: New Family Members, New Binding Partners, New Roles

Robert E. Rhoads

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Gastroenterology & Hepatology

MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

Robert M. Rowlett et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Biochemistry & Molecular Biology

The Autistic Neuron: Troubled Translation?

Raymond J. Kelleher et al.

Article Oncology

eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling

Alpana Soni et al.

MOLECULAR CANCER THERAPEUTICS (2008)

Article Biotechnology & Applied Microbiology

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman et al.

NATURE BIOTECHNOLOGY (2008)

Article Cell Biology

Dissecting eIF4E action in tumorigenesis

Hans-Guido Wendel et al.

GENES & DEVELOPMENT (2007)

Article Biochemistry & Molecular Biology

The selectivity of protein kinase inhibitors: a further update

Jenny Bain et al.

BIOCHEMICAL JOURNAL (2007)

Article Medicine, Research & Experimental

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Jeremy R. Graff et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Characterization of the activity of human MAP kinase-interacting kinase Mnk1b

Ana O'Loghlen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Biochemistry & Molecular Biology

hnRNP A1 relocalization to the stress granules reflects a role in the stress response

Sonia Guil et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Regulation of sprouty stability by Mnk1-dependent phosphorylation

J DaSilva et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Anatomy & Morphology

eIF4E as a marker for cervical neoplasia

J Matthews-Greer et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2005)

Review Biochemistry & Molecular Biology

eIF-4E expression and its role in malignancies and metastases

A De Benedetti et al.

ONCOGENE (2004)

Review Biochemistry & Molecular Biology

eIF4E - from translation to transformation

Y Mamane et al.

ONCOGENE (2004)

Article Multidisciplinary Sciences

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

HG Wendel et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Phosphorylation of Mnk1 by caspase-activated pak2/γ-PAK inhibits phosphorylation and interaction of eIF4G with Mnk

KC Orton et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Hematology

Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology

A Pellagatti et al.

BRITISH JOURNAL OF HAEMATOLOGY (2004)

Article Biochemistry & Molecular Biology

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

D Ruggero et al.

NATURE MEDICINE (2004)

Review Biochemistry & Molecular Biology

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

GC Scheper et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

Review Oncology

Clinical relevance of MGMT in the treatment of cancer

SL Gerson

JOURNAL OF CLINICAL ONCOLOGY (2002)

Article Biochemistry & Molecular Biology

Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases

Y Hefner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)