相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Covalent Small Molecules as Enabling Platforms for Drug Discovery
Samuel E. Dalton et al.
CHEMBIOCHEM (2020)
Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs
Ronen Gabizon et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering
Madita Wolter et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products
Madita Wolter et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers
Eline Sijbesma et al.
ACS CHEMICAL BIOLOGY (2020)
Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials
Haiying Lu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers
Eline Sijbesma et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Efrat Resnick et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Bifunctional chemical probes inducing protein-protein interactions
Chiara Maniaci et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2019)
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
Vittoria Zoppi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72
Jonathan Pettinger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Blake E. Smith et al.
NATURE COMMUNICATIONS (2019)
SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
Michael J. Roy et al.
ACS CHEMICAL BIOLOGY (2019)
Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures
Daniel A. Erlanson et al.
CELL CHEMICAL BIOLOGY (2019)
Cooperativity basis for small-molecule stabilization of protein-protein interactions
Pim J. de Vink et al.
CHEMICAL SCIENCE (2019)
Modulators of 14-3-3 Protein-Protein Interactions
Loes M. Stevers et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments
Kenneth K. Hallenbeck et al.
SLAS DISCOVERY (2018)
Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition
Samuel E. Dalton et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Delineating the role of cooperativity in the design of potent PROTACs for BTK
Adelajda Zorba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Electron diffraction data processing with DIALS
Max T. B. Clabbers et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
Daniel P. Bondeson et al.
CELL CHEMICAL BIOLOGY (2018)
Subunit-Specific Role of NF-kappa B in Cancer
Barbara Kaltschmidt et al.
BIOMEDICINES (2018)
Small-molecule stabilization of the p53-14-3-3 protein-protein interaction
Richard G. Doveston et al.
FEBS LETTERS (2017)
Structural basis of PROTAC cooperative recognition for selective protein degradation
Morgan S. Gadd et al.
NATURE CHEMICAL BIOLOGY (2017)
14-3-3 Isoforms Differentially Regulate NFκB Signaling in the Brain After Ischemia-Reperfusion
Xin-yu Zhou et al.
NEUROCHEMICAL RESEARCH (2017)
Lysine-Targeting Covalent Inhibitors
Jonathan Pettinger et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56
Jonathan Pettinger et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease
Donna Oksenberg et al.
BRITISH JOURNAL OF HAEMATOLOGY (2016)
Efficient nuclear export of p65-IκBα complexes requires 14-3-3 proteins (vol 119, pg 3695, 2006)
Cristina Aguilera et al.
JOURNAL OF CELL SCIENCE (2016)
Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
Georg Petzold et al.
NATURE (2016)
Small molecules, big targets: drug discovery faces the protein-protein interaction challenge
Duncan E. Scott et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Twenty years on: the impact of fragments on drug discovery
Daniel A. Erlanson et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Novel NF-κB inhibitors: a patent review (2011-2014)
Sateesh Kumar Arepalli et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2015)
Metabolism of the taxanes including nab-paclitaxel
Markus Joerger
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2015)
Modulators of Protein-Protein Interactions
Lech-Gustav Milroy et al.
CHEMICAL REVIEWS (2014)
Covalent docking of large libraries for the discovery of chemical probes
Nir London et al.
NATURE CHEMICAL BIOLOGY (2014)
Inhibition of Specific NF-κB Activity Contributes to the Tumor Suppressor Function of 14-3-3σ in Breast Cancer
Julia Ingles-Esteve et al.
PLOS ONE (2012)
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
Molecular replacement with MOLREP
Alexei Vagin et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Small molecule conformational preferences derived from crystal structure data. A medicinal chemistry focused analysis
Ken A. Brameld et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)
Cooperativity in macromolecular assembly
James R. Williamson
NATURE CHEMICAL BIOLOGY (2008)
Model preparation in MOLREP and examples of model improvement using X-ray data
Andrey A. Lebedev et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2008)
Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
C Nakanishi et al.
NATURE REVIEWS CANCER (2005)
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
MR Arkin et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
NF-κB regulation in the immune system
QT Li et al.
NATURE REVIEWS IMMUNOLOGY (2002)