期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 64, 期 14, 页码 9711-9731出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.1c00498
关键词
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资金
- SERB, DST [EMR/2017/000520]
- Guru Nanak Dev University, Amritsar
- University Grants Commission (UGC), New Delhi
This review highlights the efficacy of ivermectin in controlling malaria through vector control and effective chemoprevention to reduce parasite transmission and related fatalities.
Finding new chemotherapeutic interventions to treat malaria through repurposing of time-tested drugs and rigorous design of new drugs using tools of rational drug design remains one of the most sought strategies at the disposal of medicinal chemists. Ivermectin, a semisynthetic derivative of avermectin B-1, is among the efficacious drugs used in mass drug administration drives employed against onchocerciasis, lymphatic filariasis, and several other parasitic diseases in humans. In this review, we present the prowess of ivermectin, a potent endectocide, in the control of malaria through vector control to reduce parasite transmission combined with efficacious chemoprevention to reduce malaria-related fatalities.
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