期刊
FOOD SCIENCE AND BIOTECHNOLOGY
卷 25, 期 6, 页码 1761-1766出版社
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-016-0268-3
关键词
antioxidants; Dendropanax morbifera Leveille stem extract; hippocampus; hypothyroidism; oxidative stress
资金
- Business for Cooperative R&D between Industry, Academy, and Research Institute [c0348815]
- Research Institute for Veterinary Science, Seoul National University
In this experiment, we verified the effects of Dendropanax morbifera Leveille stem extract (DMS) on hypothyroidism-induced oxidative stress in the hippocampus of rats. Hypothyroidism was induced in rats by treating them with 0.03% 2-mercapto-1-methyl-imidazole dissolved in drinking water for 5 weeks. DMS (100 mg/kg) was also orally administered to the rats during the same period and the animals were sacrificed at 12 weeks of age. DMS administration tended to ameliorate these hypothyroidism-induced changes in serum triiodothyronine (T-3), thyroxine (T-4), and thyroid-stimulating hormone levels. DMS administration significantly reduced the hypothyroidism-induced increases in reactive oxygen species production as well as in lipid peroxidation in the hippocampus. In addition, DMS administration increased hippocampal Cu, Zn-superoxide dismutase (SOD1), catalase (CAT), and glutathione peroxidase (GPx) levels. These results suggest that DMS potentially ameliorates hypothyroidism-induced neuroendocrine phenotypes and oxidative stress in the hippocampus via the induction of antioxidant enzymes.
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