期刊
JOURNAL OF LIGHTWAVE TECHNOLOGY
卷 39, 期 12, 页码 3950-3960出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JLT.2020.3035820
关键词
Scattering; Speckle; Biology; Optical scattering; Adaptive optics; Surface plasmons; Proteins; Particle tracking; interference; speckle; electromagnetic surface waves; plasmons; electromagnetic scattering by rough surfaces
资金
- Engineering and Physical Sciences Research Council (EPSRC) [1992728]
- Royal Society
- EPSRC [1992728] Funding Source: UKRI
This technique utilizes interferometric detection and the strong field confinement of surface plasmons to track small bio-particles with sub-wavelength accuracy and robustness to noise, overcoming the limitations of weak signal strengths and scattering impurities.
Label free tracking of small bio-particles such as proteins or viruses is of great utility in the study of biological processes, however such experiments are frequently hindered by weak signal strengths and a susceptibility to scattering impurities. To overcome these problems we here propose a novel technique leveraging the enhanced sensitivity of both interferometric detection and the strong field confinement of surface plasmons. Specifically, we show that interference between the field scattered by an analyte particle and a speckle reference field, derived from random scattering of surface plasmons propagating on a rough metal film, enables particle tracking with sub-wavelength accuracy. We present the analytic framework of our technique and verify its robustness to noise through Monte Carlo simulations.
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