期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 111, 期 4, 页码 877-891出版社
OXFORD UNIV PRESS
DOI: 10.1002/JLB.2RU0221-088RRR
关键词
B cell development; BAFFR; BCR; IL-7R; pre-BCR; signal; therapeutic strategy
资金
- National Natural Science Foundation of China [31970839, 31900654]
- HUST Academic Frontier Youth Team [2018QYTD10]
- Independent Innovation Research Fund of Huazhong University of Science and Technology [2020kfyXGYJ017]
B cells play a crucial role in humoral immune responses, with ongoing research into their development and signaling pathways offering new possibilities for disease treatment.
B cells are essential for Ab production during humoral immune responses. From decades of B cell research, there is now a detailed understanding of B cell subsets, development, functions, and most importantly, signaling pathways. The complicated pathways in B cells and their interactions with each other are stage-dependent, varying with surface marker expression during B cell development. With the increasing understanding of B cell development and signaling pathways, the mechanisms underlying B cell related diseases are being unraveled as well, making it possible to provide more precise and effective treatments. In this review, we describe several essential and recently discovered signaling pathways in B cell development and take a look at newly developed therapeutic strategies targeted at B cell signaling.
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