The RATIOnal Role of Polyamines in Epidermal Differentiation

Polyamines have been implicated in skin tumorigenesis; however, their role in epidermal homeostasis remains obscure. In a new article in the Journal of Investigative Dermatology, Rahim et al. (2021) report that keratinocyte differentiation requires a shift in polyamine ratios that is mediated by AMD1. Results suggest that targeting polyamine availability might be useful in the treatment of hyperproliferative skin disorders.

Automated summary

Polyamines play a critical role in keratinocyte differentiation, with AMD1 mediating the shift in polyamine ratios. Targeting polyamine availability may be beneficial in treating hyperproliferative skin disorders.