4.7 Editorial Material

Ode to Salt: Commentary on Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity

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JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 142, 期 1, 页码 16-17

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2021.06.014

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  1. National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (Bethesda, MD) [R01 AR051930, R01 AR061106]

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The study demonstrated that skin sodium ion (Na+) is increased in patients with psoriasis, particularly those with a PASI > 5, and correlates with disease severity. The findings support a proposed mechanism where increased Na+ concentrations enhance IL-17 expression from CD4(+) cells. These results suggest a novel pathologic mechanism for psoriasis development and potential target for treatment.
Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity (Maifeld et al., 2021) showed that skin sodium ion (Na+) is increased in patients with a PASI > 5. Na+ concentration as well as its content were increased in these patients, supporting the proposed mechanism that increased Na+ concentrations enhance IL-17 expression from CD4(+) cells. These data initially were generated using a noninvasive technique, sodium (Na-23) magnetic resonance imaging, and then were verified using Na-23 spectroscopy and atomic absorption spectrometry in ashed-skin biopsies in humans and also using mouse models of psoriasis. These findings suggest a novel pathologic mechanism for psoriasis development and target for treatment.

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