☆ 4.7 Editorial Material

Clarifying Progress on the Genomic Landscape of Actinic Keratosis

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis

Qi Zheng et al.

Summary: The study used DNA and RNA sequencing to analyze the development of SCCIS, revealing associations between UV radiation and mutations in multiple genes. The frequency and distribution of NOTCH and TP53 gene mutations suggest that NOTCH mutations may precede TP53 mutations. The upregulation of the NEURL1 ubiquitin ligase in SCCIS may represent a mechanism for downregulating Notch during UV-induced carcinogenesis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Dermatology

The Genomic Landscape of Actinic Keratosis

Jason Thomson et al.

Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Immunology