期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 220, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2021.111463
关键词
Polyoxometalates; Bacterial hyperpolarization; Antibiotic resistance; Ion influx; Anti-biotics; Ionic interaction
资金
- National Natural Science Foundation of China [21961142018, U1832220, 51873067]
- Natural Science Foundation of Guangdong Province [2021A1515010271, 2021A1515012024]
Combining Preyssler-type polyoxometalates (POMs) with ribosome-targeting antibiotics shows high antibacterial efficiency with low risk of antibiotic resistance by affecting bacterial cell membranes and ribosome structures. Regulating bacterial growth by inducing a 'dormant' state in bacteria with POMs at early growth stages followed by antibiotic exposure demonstrates a validated approach for combating antibiotic resistant bacteria.
Developing strategies against the antibiotic resistance is a major global challenge for public health. Here, we report the synergy of the combination of Preyssler-type polyoxometalates (POMs) ([NaP5W30O110](14-)) or [AgP5W30O110](14-)) ) and ribosome-targeting antibiotics for high antibacterial efficiency with low risk of antibiotic resistance. Due to their ultra-small sizes and active surface ligands, POM anions show strong affinity to bacterial cell membrane and impose hyperpolarization of the bacterial cells as well as the decrease of Mg2+ influx by blocking Mg2+ transporters, which finally lead to the structural perturbations of ribosomes and instability of bacterial structures. The bacterial growth can, therefore, be regulated by the presence of POMs: a fraction of Bacillus subtilis shifted to a 'dormant', slow-growing cellular state (an extended lag phase) upon the application of subinhibitory concentration of POMs. An approach to combat antibiotic resistant bacteria by applying POMs at their early growth phase followed by antibiotic exposure is validated, and its high efficiency for bacterial control is confirmed.
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