期刊
JOURNAL OF INFECTIOUS DISEASES
卷 224, 期 -, 页码 S821-S828出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiab475
关键词
ETEC; mucosal immune responses; vaccine
资金
- PATH [OPP1112376]
- United Kingdom (UK)'s Foreign and Commonwealth Development Office [204139-101]
- Swedish Research Council
- Swedish Foundation for Strategic Research [SB12-0072]
The ETVAX oral vaccine demonstrated the potential to induce strong mucosal immune responses in a majority of vaccinated Swedish adults and individuals of different age groups, including infants, in Bangladesh, showing promise in combating enterotoxigenic Escherichia coli infections.
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of mortality and morbidity in children in low-income countries. We have tested an oral ETEC vaccine, ETVAX, consisting of inactivated E coli overexpressing the most prevalent colonization factors and a toxoid, LCTBA, administered together with a mucosal adjuvant, double-mutant heat-labile toxin (dmLT), for capacity to induce mucosal immune responses and immunological memory against the primary vaccine antigens, ie, colonization factors, heat-labile toxin B-subunit and O antigen. The studies show that ETVAX could induce strong intestine-derived and/or fecal immune responses in a majority of vaccinated Swedish adults and in different age groups, including infants, in Bangladesh.
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